bYlok® bispecific pairing technology in bsAb production
Lonza’s bYlok® bispecific pairing technology is an innovative solution designed to enhance the development and production of bispecific antibodies.
By addressing the challenge of heavy-light chain mispairing, bYlok® bispecific pairing technology ensures high accuracy in antibody assembly, making it a crucial innovation in the field of antibody production and a valuable tool in our bispecific antibody production services.
120.000 +
95% +
4 weeks
bYlok® bispecific pairing technology – an overview
The bYlok® bispecific pairing technology revolutionizes bispecific antibody production by ensuring correct heavy-light chain pairing, which is crucial for the functionality and efficacy of these antibodies, but has been a major issue when producing them.
With bYlok® bispecific pairing technology, we can achieve over 95% correct heavy chain-light chain pairing by modifying the position of the disulfide bond from the constant region to the variable region of the antibody. This adjustment drives the correct assembly of heavy and light chains, minimizing the production of disassembled antibody species.
Interested to find out more details about bYlok® bispecific pairing technology? Download Lonza’s brochure on this innovative technology!
License agreement – evitria gains access to Lonza’s bYlok® bispecific pairing technology
In a strategic move to enhance our bispecific production capabilities, evitria has entered into a non-exclusive license agreement with Lonza. This agreement grants evitria access to Lonza’s bYlok® bispecific pairing technology, enabling us to produce bispecific antibodies with improved precision and efficiency.
This collaboration allows evitria to offer rapid transient production of bispecific molecules, facilitating early-stage antibody discovery and drug development studies as well as larger-scale production runs of biologics and biotherapeutics.
Benefits of bYlok® bispecific pairing technology in bsAb production
The integration of bYlok® bispecific pairing technology platform into bispecific antibody production offers several key benefits:
- High precision – achieves over 95% correct HC-LC pairing, significantly reducing misassembled species
- Natural structure – allows the production of IgG-like bispecifics, ensuring stability and minimizing immunogenicity
- Enhanced yield – compatible with existing CHO cell line systems, enabling high yield and efficient production of heterodimers
- Streamlined processing – streamlines downstream processing by minimizing unwanted homodimers, thus improving overall manufacturing efficiency
Applications of bispecific antibodies produced with bYlok® bispecific pairing technology
Bispecific antibodies produced using the bYlok® bispecific pairing technology have a wide range of applications in therapeutic and diagnostic fields:
- Cancer therapy – enhanced targeting of cancer cells or cross linking of cancer and immune-effector cells
- Autoimmune diseases – potential to modulate immune responses with higher specificity
- Infectious diseases – improved targeting of pathogens with reduced risk of resistance development
Bispecific antibodies – evitria has got you covered
With the integration of bYlok® bispecific pairing technology, evitria is well-equipped to meet the diverse needs of bispecific antibody research and development. Not only are we able to express bsAbs in different formats – from the Duobody system (Genmab) and IgG-scFvs to Knobs-into-Holes, Electrostatic Steering, bYlok® bispecific pairing technology, and Crossmab, but we can also support you in finding out which format is the best choice for you.
Whether you are just starting to explore bispecific antibodies, or have a late-preclinical stage candidate, evitria’s advanced capabilities as well as our collaborative partner network of industry leaders ensure high-quality and reliable antibody production. Our streamlined processes and rapid production timelines mean that you can rely on your bispecific antibodies in as little as four weeks.
FAQs
What is the bYlok® bispecific pairing technology by Lonza?
+How does bYlok® bispecific pairing technology work?
How does bYlok® bispecific pairing technology work?
+What are the advantages of producing bispecific antibodies with bYlok® bispecific pairing technology?
What are the advantages of producing bispecific antibodies with bYlok® bispecific pairing technology?
+– High precision in HC-LC pairing
– Maintenance of natural antibody structure
– Compatibility with numerous expression systems
– Streamlined downstream processing
– High yield and stability
Why does evitria have access to Lonza’s bYlok® bispecific pairing technology?
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Our team of experts is looking forward to talk with you about your plans, concerns and expectations regarding our expression services.
